MB12

1. cyanocobalamin
2. hydroxycobalamin
3. adenosylcobalamin
4. glutathionylcobalamin
5. methylcobalamin

MB12 is a Methyl Donor, which means it is the only B12 that has the ability to activate the methionine / homocysteine biochemical pathway directly as shown in the pathway.

Benefits with Proper MB12 usage are as follows Ref: (Dr. James Neubrander, USA): 94% children improve to varying degrees Awareness, cognition, appropriateness, eye contact when called 80% improve in speech and language 70% show improved socialization & emotion As per Parent Designed Report Form: 50% of responders have more than 28/136 responses: This group has excellent prognosis if therapy is maintained for 2 to 3 years Balance 50% respond very well if therapy is as above Some children will lose their diagnosis Four Folic Acid molecules combine to form Tetra-Hydro-Folate. The enzyme, MTHFR combines a "Methyl Radical" to it, which is transferred to the carrier substance cobalamin (B12), converting it to Methyl B12. The MB12 passes the "Methyl" radical to the harmful amino acid: Homocysteine, converting it to the useful Methionine. Methionine crosses the blood-brain barrier to release the "Methyl". It has two major functions: it marks the beginning and end of the part of the RNA/DNA chain that marks out how to make a protein or enzyme or other chemical as needed by the cell. In addition, it is necessary to methylate and activte the Dopamine D4 receptor, without which it will not attach Dopamine to regulate emotion and behavior. It is also needed for other metabolic activities within the brain and nerves. Many Autistic children have a deficiency of MTHFR enzyme, hence lack ability to make adequate amounts of MB12. This can be tested by appropriate biochemical tests available in India.

• Mb12 revives neuronal pathways. The revived pathways may initially overload sensory inputs (like hearing impaired person wearing Hearing Aid for the first time).
• Sensory overload may initially produce bizarre behavior till child learns to filter out excessive inputs as we do: time: 6 week; minimum up to 6 month.
• Facial: Increased activity level, sleep disturbance, increased mouthing of objects
• Later: Paraesthesia,
• Increasingly aware of their wants & desires & frustrated +++ when denied it Vs. normal kids
• Increased mouthing of objects
• PICA rare.
• Bites on furniture, shirt, shirtsleeves, etc.
• Feel tongue is buzzing / tickling
• Long nerves to arms and legs take longer to manifest S/E and resolution (6 to 9 months)
• Sleep restoration more common than disturbance since melatonin production is reduced
• The greater the acceptable side effects, better the long term prognosis. If unacceptable, STOP, reduce dosage or give other Rx.
• Disturbance resolves within 2 to 6 months