Maternal age as a risk factor for occurrence of Down Syndrome

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Age (years) Frequency of Fetuses with Down
Syndrome to Normal Fetuses
at 16 weeks of pregnancy
Frequency of Live Births of
Babies with Down Syndrome
to Normal Births

15 - 19

----

1 / 1250

20 - 24

----

1 / 1400

25 - 29

----

1 / 1100

30 - 31

----

1 / 900

32

----

1 / 750

33

1 / 420

1 / 625

34

1 / 325

1 / 500

35

1 / 250

1 / 350

36

1 / 200

1 / 275

37

1 / 150

1 / 225

38

1 / 120

1 / 175

39

1 / 100

1 / 140

40

1 / 75

1 / 100

41

1 / 60

1 / 85

42

1 / 45

1 / 65

43

1 / 35

1 / 50

44

1 / 30

1 / 40

45 and older

1 / 20

1 / 25

The zone written with yellow font is an increased risk zone while the zone written with red font is a high risk zone. The middle column above showing the occurrence rates at 16 weeks of pregnancy is mentioned because as per natural laws of survival of the fittest, many abnormal fetuses abort by this time.

Adapted from Hook EB. Journal of Am. Med. Assoc.; Vol. 249: Page 2034-2038, Year 1983.